Friday, May 8, 2009

The Land of Pharma 3 - Buildings

First – obvious but easily overlooked – a building is needed. The WMC is a huge and rich company that makes a wide variety of products, so you'd expect WMC products to be made in nice buildings. You'd be right – mostly. In the United States, the Food and Drug Administration (the FDA) has oversight for medicines. "Oversight" includes the buildings the medicines are made in. Each building must be licensed (approved) for use. The approval process is a long and difficult (and costly) so once licensed for production, it's unlikely that WMC or any other large company would willingly put themselves through that task for fun.
Let's make sure that's clear. The news does a good job of telling everyone when a new pharmaceutical product is approved by the FDA. But the building that it's made in has to be approved too? Yes, indeed. So when WMC first developed Hemopres and Menengevax, it first had to ensure it had a place to produce them.
This wasn't all that difficult for Hemopres. WMC has been making non-sterile small molecule pharmaceuticals for years (in Imaginationland, where this running example takes place). The company already had multiple buildings outfitted with all the necessary equipment to manufacture Hemopres. All they needed was the API, really, and they have multiple API sites already.
The story is different for Menengevax. Where pressing powder into tablets is relatively straight-forward, vaccines are biological systems and each vaccine is different. So each vaccine manufacturing process is different. And every building is different.
But regardless of the product inside, buildings still have their own needs. Heat and air conditioning, for example. Then there's the roof. Most manufacturing buildings have flat roofs so the heater and air conditioner (collectively known as "air handlers") can be put up there, but flat roofs are notorious for leaking as well. Under that roof are offices, hallways, bathrooms that all need cleaning and maintenance. And this is to say nothing about the actual manufacturing process.
Further, the toilets have to get hooked up to the sewers. Electricity lines have to run to the building. And the property surrounding that building is taxed, of course. So despite the fact that there are difficult scientific processes happening in that building, it has all the same, mundane, run-of-the-mill issues that a house has. And parking is a bitch.
So now WMC has a building. But that's WMC. That's just one "Big Pharma" scenario. There's a lot of other ways to fulfill the "building" requirement. And this was obviously a sketch overview, at best. From here, we'll get into some details.

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